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Having skin checks conducted by a health professional may be even more vital than previously thought, with research showing that cancer may lurk in ‘normal’ looking skin.

Skin with few visible freckles or blemishes may still carry sun-damaged DNA mutations that can trigger cancer, warn University of Queensland researchers.

The University of Queensland’s (UQ) Frazer Institute Dermatology Research Centre investigated the relationship between the number of mutations found in ‘normal looking’ skin and the number of a person’s past skin cancers.

Disturbingly, the findings show Australians can still have a high number of mutations in skin they think looks normal, said lead author and UQ PhD candidate Ms Ho Yi Wong.

“We took skin samples from the forearms of 37 skin cancer patients which were frequently sun exposed. They had an average of 4-5 times more mutations in normal looking skin compared to similar studies overseas.

“The higher mutation levels are likely due to Australia having 2-4 times higher levels of ultra-violet light than the United Kingdom and Europe.”

The study next matched people of the same age and sex who had a different number of skin cancers. One group had many skin cancers and the other group had few to none in the past five years.

“We found a 45% difference between the groups, with a much larger number of mutations on the forearms of those with more skin cancers,” Ms Wong said.

Around two-thirds of Australians will develop a skin cancer during their lifetime.

The findings explain in part why people with a single skin cancer have a much higher chance of developing others in the same area of the body in the future, said senior author Professor Kiarash Khosrotehrani.

“The findings also suggest that if we reduce mutation levels in normal looking skin then we could reduce the risk of new skin cancers,” he said.

“We found laser treatments and dermabrasion can ‘wipe away’ skin mutations and reduce the risk of skin cancer, but this approach is not applicable to everyone.

“Lasers and dermabrasion are difficult and expensive to implement at large scale, which is why other therapies are needed.

“Our next step is to explore therapies that can reduce the load of skin mutations.”

The research is published in the journal Science Advances.