Breastfeeding mothers could potentially vaccinate their babies naturally against malaria, a new study has revealed.
Researchers from the University of Western Australia (UWA) investigated whether two proteins from malaria parasites were detectable in the breastmilk of mothers from Uganda, a country where malaria is widespread.
The results showed that 15% of breastmilk samples from mothers who carry the malaria parasites without symptoms, contain malaria antigens in their breastmilk.
The researchers proposed these mothers may be the ones able to naturally vaccinate their child against malaria as their breastmilk would contain malaria proteins together with additional factors specifically adapted to the babies’ immune system.
Study Lead Professor Valerie Verhasselt, from UWA’s School of Molecular Sciences said the research introduced a new concept that could be tested to prevent the spread of malaria.
“More than 200 million cases of malaria are reported each year around the world, with the majority in Africa,” she said.
“Infants aged under five years account for two-thirds of all malaria deaths, highlighting the need for early and efficient prevention of malaria infection.”
Professor Verhasselt said breastfeeding was the most efficient way to prevent childhood disease and death related to respiratory and gastrointestinal infectious disease.
“Before this study, there was conflicting evidence on whether breastfeeding could prevent malaria and we wanted to find a way to ensure malaria prevention through breastfeeding.
“Based on our longstanding expertise in the field of allergy prevention through breastfeeding, we propose the original hypothesis that the presence of malaria antigen (proteins) in breastmilk stimulates anti-malarial immune defence and reduces malaria risk in breastfed infants. This would be a way to naturally vaccinate infants.”
The researchers said the next step was to carry out clinical trials to assess immunological outcomes and malaria risk in infants exposed to one or multiple malaria antigens through breastmilk.
“We could then propose to vaccinate breastfeeding mothers to increase levels of malaria antigen in breastmilk, ensuring vaccination and long-term protection of their child,” Professor Verhasselt said.
